The Four Pathogenic Factors Involved in AcneAn increase in the levels of androgens before and during adolescence leads to the production of greater amounts of sebum.The bacterium Propionibacterium acnes, which is resident on the skin of even healthy individuals, thrives on sebum. Increased sebum production in acne patients results in a proliferation of this micro-organism.Something goes awry in the infundibulum of the follicle in acne patients that causes cells from the follicle wall to clump together. This abnormal keratinization results in the clogged pores, or microcomedones, that can later proceed to other acne lesions.The presence of P acnes triggers the release of chemotactic factors that cause inflammation, as manifested by papules, pustules, and nodules.
Now if bacterium infects a whitehead, a papule or pustule- a pimple forms. Such acne is inflammatory by nature and can be from mild to severe in nature. In very severe cases of acne, cysts and nodules develop, rupture and spread infection thereby causing permanent scars.
• Application of the juice of a fresh papaya along with its seeds and skin on the affected area will reduce the swelling and redness. It should however be washed off with warm water after sometime.
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